B-Cell Neoplasms |
Immature B-Cell Neoplasms |
Lymphoblastic leukemia (see Chap. 55) | Medium to large cells with finely stippled chromatin and scant cytoplasm | TdT+, sIg-, CD10+, CD13+/-, CD19+, CD20-, CD22+, CD34+/-, CD33+/-, CD45+/-, CD79a+ | t(1;19), t(9;22), and defects at 11q23-defects associated with poor prognosis |
Lymphoblastic lymphoma (see Chap. 65) | Medium-sized cells with high nuclear to cytoplasmic ratio | See above | See above |
Mature B-cell Neoplasms |
Leukemias | | | |
Chronic lymphocytic leukemia (see Chap. 56) | Small cells with round, dense nuclei | sIg+(dim), CD5+, CD10-, CD19+, CD20+(dim), CD22+(dim), CD23+, CD38+/-, CD45+, FMC-7- | IgR, trisomy 12 (~30%), del at 13q14 (~50%), 11q- (15%) |
Prolymphocytic leukemia (see Chap. 56) | ≥55% prolymphocytes | sIg+(bright), CD5+/-, CD10-, CD19+, CD22+, CD23+/-, CD45+ | IgR, trisomy 12 (~30%) |
Hairy cell leukemia (see Chap. 57) | Small cells with cytoplasmic projections | sIg+(bright), CD5-, CD10-, CD11c+(bright), CD19+, CD20+, CD25+, CD45+, CD103+, Annexin A+ | IgR, |
Lymphomas | | | |
Small lymphocytic lymphoma (see Chap. 56) | Small round ... |