Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + Download Section PDF ++ Bruce A. Chabner, MD ++ Professor of Medicine ++ Harvard Medical School ++ Director of Clinical Research ++ Massachusetts General Hospital Cancer Center ++ Boston, Massachusetts ++ ++ Dan L. Longo, MD ++ Professor of Medicine ++ Harvard Medical School ++ Senior Physician ++ Brigham and Women's Hospital ++ Deputy Editor ++ New England Journal of Medicine ++ Boston, Massachusetts