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APPENDIX: LABORATORY VALUES OF CLINICAL IMPORTANCE

Alexander Kratz; Michael A. Pesce; Robert C. Basner; Andrew J. Einstein

INTRODUCTION

This Appendix contains tables of reference values for laboratory tests, special analytes, and special function tests. A variety of factors can influence reference values. Such variables include the population studied, the duration and means of specimen transport, laboratory methods and instrumentation, and even the type of container used for the collection of the specimen. The reference or "normal" ranges given in this appendix may therefore not be appropriate for all laboratories, and these values should only be used as general guidelines. Whenever possible, reference values provided by the laboratory performing the testing should be utilized in the interpretation of laboratory data. Values supplied in this Appendix reflect typical reference ranges in adults. Pediatric reference ranges may vary significantly from adult values.

In preparing the Appendix, the authors have taken into account the fact that the system of international units (SI, système international d'unités) is used in most countries and in some medical journals. However, clinical laboratories may continue to report values in "traditional" or conventional units. Therefore, both systems are provided in the Appendix. The dual system is also used in the text except for (1) those instances in which the numbers remain the same but only the terminology is changed (mmol/L for meq/L or IU/L for mIU/mL), when only the SI units are given, and (2) most pressure measurements (e.g., blood and cerebrospinal fluid pressures), when the traditional units (mmHg, mmH2O) are used. In all other instances in the text, the SI unit is followed by the traditional unit in parentheses.

REFERENCE VALUES FOR LABORATORY TESTS

TABLE 1HEMATOLOGY AND COAGULATION
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TABLE 1HEMATOLOGY AND COAGULATION
ANALYTE SPECIMEN SI UNITS CONVENTIONAL UNITS
Activated clotting time WB 70–180 s 70–180 s
Activated protein C resistance (factor V Leiden) P Not applicable Ratio >2.1
ADAMTS13 activity P ≥0.67 ≥67%
ADAMTS13 inhibitor activity P Not applicable ≤0.4 U
ADAMTS13 antibody P Not applicable ≤18 U
Alpha2 antiplasmin P 0.87–1.55 87–155%
Antiphospholipid antibody panel
 PTT-LA (lupus anticoagulant screen) P Negative Negative
 Platelet neutralization procedure P Negative Negative
 Dilute viper venom screen P Negative Negative
 Anticardiolipin antibody S
  IgG 0–15 arbitrary units 0–15 GPL
  IgM 0–15 arbitrary units 0–15 MPL
Antithrombin III P
 Antigenic 220–390 mg/L 22–39 mg/dL
 Functional 0.7–1.30 U/L 70–130%
Anti-Xa assay (heparin assay) P
 Unfractionated heparin 0.3–0.7 kIU/L 0.3–0.7 IU/mL
 Low-molecular-weight heparin 0.5–1.0 kIU/L 0.5–1.0 IU/mL
 Danaparoid (Orgaran) 0.5–0.8 kIU/L 0.5–0.8 IU/mL
Autohemolysis test WB 0.004–0.045 0.4–4.50%
Autohemolysis test with glucose WB 0.003–0.007 0.3–0.7%
Bleeding time (adult) <7.1 min <7.1 min
Bone marrow: See Table 7
Clot retraction WB 0.50–1.00/2 h 50–100%/2 h
Cryofibrinogen P Negative Negative
D-dimer P 220–740 ng/mL FEU 220–740 ng/mL FEU
Differential blood count WB
Relative counts:
 Neutrophils 0.40–0.70 40–70%
 Bands 0.0–0.05 0–5%
 Lymphocytes 0.20–0.50 20–50%
 Monocytes 0.04–0.08 4–8%
 Eosinophils 0.0–0.6 0–6%
 Basophils 0.0–0.02 0–2%
Absolute counts:
 Neutrophils 1.42–6.34 × 109/L 1420–6340/mm3...

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