The age-adjusted incidence rate of ALL is 1.6 per 100,000 men and women per year in the United States.
— It is estimated that 5320 cases (3140 males and 2180 females) were diagnosed in 2014 in the United States.
— The median age at diagnosis for ALL is 13 years, and approximately 61% of cases are diagnosed before the age of 20 years.
— ALL is the most common malignancy diagnosed in patients younger than age 15 years, accounting for 23% of all cancers and 76% of all leukemias in this age group.
Only 20% of adult acute leukemias have a lymphocytic phenotype.
Age-specific incidence patterns are characterized by a peak between the ages of 2 and 4 years, followed by falling rates during later childhood, adolescence, and young adulthood (Figure 54–1).
Incidence rises again in the sixth decade.
The incidence of ALL differs substantially in different geographic areas.
— Rates are higher among populations in northern and western Europe, North America, and Oceania, with lower rates in Asian and African populations.