Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content +++ PATHOGENESIS ++ Loss of hepatic parenchymal cells leads to decreased plasma levels of all plasma coagulation factors except factor VIII and von Willebrand factor. Thrombocytopenia occurs frequently and is usually a result of splenic sequestration (see Chap. 73) but may also be caused by an autoimmune mechanism, disseminated intravascular coagulation (DIC), folic acid deficiency, and decreased platelet production. Thrombocytopenia due to thrombopoietin (TPO) deficiency and platelet dysfunction contribute to the hemostatic abnormalities. Enhanced fibrinolysis is common and appears to be caused by complex pathogenetic mechanisms, including release and impaired clearance of plasminogen activators. Dysfibrinogenemia is relatively frequently found in patients with chronic liver disease. Patients with chronic liver disease may develop a consumption coagulopathy—in its most extreme form DIC. Recent studies employing sophisticated coagulation tests have shown that due to a rebalancing of the coagulation system in patients with chronic liver failure, thrombin generation is basically normal in the majority of patients, whereas some patients may have a prothrombotic phenotype. +++ CLINICAL FEATURES ++ Patients with liver disease may present with purpura, epistaxis, gingival bleeding, and/or menorrhagia. Bleeding typically follow trauma or surgical procedures, especially in sites with high fibrinolytic activity, such as the urogenital tract or oral mucosa. Patients with acute viral or toxic hepatitis usually develop abnormal bleeding only if the disease is fulminant. Bleeding from esophageal varices requires primary attention to the bleeding site as well as efforts to correct the hemostatic abnormalities. The coagulopathy of liver disease may also predispose the patient to thromboembolic complications. +++ LABORATORY FEATURES ++ Table 83–1 summarizes the laboratory abnormalities that can be found in patients with chronic liver disease. These abnormalities may both contribute to bleeding or thrombosis. Determination of plasma levels of factors V, VII, and VIII may help differentiate liver disease (factor VIII levels normal or increased; factors V and VII decreased), vitamin K deficiency (factor VII decreased; factors V and VIII normal), and DIC (all decreased). ++Table Graphic Jump LocationTABLE 83–1CHANGES IN THE HEMOSTATIC SYSTEM IN PATIENTS WITH LIVER DISEASE THAT CONTRIBUTE TO BLEEDING (LEFT) OR CONTRIBUTE TO THROMBOSIS (RIGHT)View Table||Download (.pdf) TABLE 83–1 CHANGES IN THE HEMOSTATIC SYSTEM IN PATIENTS WITH LIVER DISEASE THAT CONTRIBUTE TO BLEEDING (LEFT) OR CONTRIBUTE TO THROMBOSIS (RIGHT) Changes that Impair Hemostasis Changes that Promote Hemostasis Primary Hemostasis Thrombocytopenia Elevated levels of VWF Platelet function defects Decreased levels of ADAMTS13 Enhanced production of nitric oxide and prostacyclin Secondary Hemostasis Low levels of factors II, V, VII, IX, X, and XI Elevated levels of factor VIII Vitamin K deficiency Decreased levels of protein C, protein S, antithrombin, α2-macroglobulin, and heparin cofactor II Dysfibrinogenemia Fibrinolysis Low levels of α2-antiplasmin, factor XIII, and TAFI Low levels of plasminogen Increase in PAI-1 levels Elevated t-PA levels ADAMTS13, a disintegrin-like and metalloprotease with thrombospondin domain 13; PAI-1, plasminogen activator inhibitor 1; TAFI, thrombin-activatable fibrinolysis inhibitor; ... Your Access profile is currently affiliated with '[InstitutionA]' and is in the process of switching affiliations to '[InstitutionB]'. Please click ‘Continue’ to continue the affiliation switch, otherwise click ‘Cancel’ to cancel signing in. Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Username Error: Please enter User Name Password Error: Please enter Password Forgot Password? Forgot Username? Sign in via OpenAthens Sign in via Shibboleth