The editors and authors warmly acknowledge the support they have received in preparing this book. Nicole Goldman collated and oversaw the book's preparation, organized and formatted it. Yvonne Doyle supported Dr O'Donnell in her work. Dr Fiona Hicks advised on the chapters on palliative care and Dr Louise Hanna on the brain tumour chapter. Finally, Jane Pennington and Clinical Publishing were patient and helpful publishers whose vision for the series of Problem Solving books guided and stimulated us and without whose help the book would never have been written.