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CLASSIFICATION

  • Lymphocyte malignancies comprise a wide spectrum of different morphologic and clinical syndromes.

  • The International Lymphoma Study Group proposed a new classification termed the Revised European–American Lymphoma classification, or REAL classification, which was modified in 2001 and updated in 2008 and in 2016 by the World Health Organization (WHO) (Table 54–1).

  • The WHO classification makes use of the pathologic, immunophenotypic, genetic, and clinical features to define separate disease entities (Table 54–1).

  • Lymphocytic neoplasms are divided into those derived from B cells, T cells, or natural killer (NK) cells.

  • The immunophenotype and the characteristic cytogenetic and genic abnormalities are also included in Table 54–1.

  • The most common indolent and aggressive lymphocytic neoplasms, based on their usual clinical behavior, are listed in Tables 54–2 and 54–3.

TABLE 54–1CLASSIFICATION OF LYMPHOMA AND LYMPHOID LEUKEMIA BY THE WORLD HEALTH ORGANIZATION

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