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ABBREVIATIONS

Abbreviations

ABC: ATP-binding cassette

ABL: Abelson murine leukemia viral oncogene homolog

ALK: anaplastic lymphoma kinase

ALL: acute lymphoblastic leukemia

AML: acute myelocytic leukemia

APML: acute promyelocytic leukemia

ARNT: aryl hydrocarbon receptor nuclear translocator (also known as HIF-1β)

ATO: arsenic trioxide

AUC: area under the curve

BCC: basal cell carcinoma

BCL: B-cell lymphoma

BCR: breakpoint cluster region (chr22)

BCRP: breast cancer resistance protein

BH: BCL2 homology domain

BIM: BCL2-like protein 11

BRCA: breast cancer susceptibility gene

BRK: breast tumor kinase, PTK6

BTK: Bruton tyrosine kinase

CDK: cyclin-dependent kinase

CLL: chronic lymphocytic leukemia

CML: chronic myelocytic leukemia

CRL4-CRBN: cullin-RING ubiquitin ligase cereblon complex

cuSCC: cutaneous squamous cell carcinoma

CXCR4: C-X-C chemokine receptor 4

DNMT: DNA methyltransferase

ECG: electrocardiogram

EGF(R): epidermal growth factor (receptor) = HER1

EML4: echinoderm microtubule-associated protein-like 4

ER: estrogen receptor

ERK: extracellular signal-related kinase = MAPK

FGF(R): fibroblast growth factor (receptor)

FIP1L1: factor interacting with poly (A) polymerase

FKBP12: immunophilin-binding protein for tacrolimus (FK506)

FL: follicular B-cell non-Hodgkin lymphoma

FLT(1 or 4): fms-related tyrosine kinase (1 or 4) (= VEGFR1 or 3)

FMO3: flavin containing monooxygenase 3

GI: gastrointestinal

GIST: gastrointestinal stromal tumor

HDAC: histone deacetylase

HER1/2: human epidermal growth factor receptor; 1 = EGFR; 2 = erbB2

2-HG: 2-hydroxyglutarate

HGF(R): hepatocyte growth factor (receptor) = cMET

HIF-1 or -2: hypoxia-inducible factor 1 or 2

HMT: histone methyltransferase

HSC: hematopoietic stem cell

IFN: interferon

IGF1R: insulin-like growth factor 1 receptor

IκB: inhibitor of nuclear factor kappa B

IL: interleukin

IMiDs: immunomodulatory imide drugs (e.g., thalidomide)

ITK: inducible T-cell kinase

KDR: kinase insert domain receptor = VEGFR2

KIT: feline sarcoma virus oncogene homolog

LCK: lymphocyte-specific kinase

MAPK: mitogen-activated extracellular signal regulated protein kinase = ERK

MCL: mantle cell lymphoma

MCyR: major cytogenetic response

MDS: myelodysplastic syndrome

MEK: mitogen-activated extracellular signal regulated protein kinase kinase = MKK

MET: mesenchymal-epithelial transition factor (= HGFR)

MM: multiple myeloma

mTOR: mammalian or mechanistic target of rapamycin

NCCN: National Comprehensive Cancer Network

NET: neuroendocrine tumor

NF-κB: nuclear factor-κB

NK: natural killer

NPM: nucleophosmin (gene)

NRAS: neuroblastoma RAS virus homolog

NSCLC: non–small cell lung cancer

OATP: organic anion-transporting polypeptide

PARP: poly(ADP-ribose) polymerase

PDGF(R): platelet-derived growth factor (receptor)

Pgp: P-glycoprotein

PI3K: phosphatidylinositol 3-kinase

PIK3CA: PI3K catalytic subunit α gene; codes for the p110α enzyme

PIP2: phosphatidylinositol 4,5-bisphosphate

PIP3: phosphatidylinositol (3,4,5)-trisphosphate

PNET: peripheral neuroendocrine tumor

PPES: palmar-plantar erythrodysesthesia syndrome

PPI: proton pump inhibitor

PROTAC: proteolysis-targeting chimera

PTEN: phosphatase and tensin homolog

Rb: retinoblastoma (protein)

RCC: renal cell carcinoma

RET: “rearranged during transfection” receptor tyrosine kinase

ROS1: orphan receptor tyrosine kinase

SDF: stromal cell-derived factor

SLL: small lymphocytic lymphoma

TGF: transforming growth factor

TIE: tyrosine kinase with Ig and EGF domains

TKI: tyrosine kinase inhibitor

TSC: tuberous sclerosis complex

VEGF(R): vascular endothelial growth factor (receptor)

VHL: von Hippel-Lindau (pVHL = VHL protein)

A Note on Treatment Regimens

Cancer treatment regimens change to reflect continuous advances in basic and clinical science. As a consequence, this chapter presents relatively few detailed treatment regimens; rather, we refer the reader ...

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