TY - CHAP M1 - Book, Section TI - Treatment of Infections in the Immunocompromised Host A1 - Beutler, Lisa A1 - Babik, Jennifer A2 - Kaushansky, Kenneth A2 - Lichtman, Marshall A. A2 - Prchal, Josef T. A2 - Levi, Marcel M. A2 - Press, Oliver W. A2 - Burns, Linda J. A2 - Caligiuri, Michael PY - 2015 T2 - Williams Hematology, 9e AB - SUMMARYInfection is a major cause of morbidity and mortality in patients with severe inherited or acquired neutropenia or aplastic anemia, qualitative disorders of neutrophils, and, notably, those persons receiving chemotherapy for treatment of hematologic neoplasms. Severe neutropenia and monocytopenia often result from the combined effects of replacement of marrow with malignant cells and superimposed intense chemotherapy. The severity and duration of the neutropenia determine the risk of infection. Bacterial infections may result in rapid clinical deterioration and even death. Fungal, viral, and parasitic infections also may result in potentially lethal complications during or after chemotherapy. This chapter considers methods of diagnosis of bacterial, fungal, viral, and protozoal infection and describes treatment regimens. Because prevention of infection during periods of neutropenia should reduce morbidity and improve outcome, attention is focused on prophylaxis against bacterial, parasitic, viral, and/or fungal infections. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1121090720 ER -