TY  - CHAP
M1  - Book, Section
TI  - Heparin-Induced Thrombocytopenia
A1  - Cuker, Adam
A1  - Poncz, Mortimer
A2  - Kaushansky, Kenneth
A2  - Lichtman, Marshall A.
A2  - Prchal, Josef T.
A2  - Levi, Marcel M.
A2  - Press, Oliver W.
A2  - Burns, Linda J.
A2  - Caligiuri, Michael
PY  - 2015
T2  - Williams Hematology, 9e
AB  - SUMMARYHeparin-induced  thrombocytopenia  (HIT)  is  a  prothrombotic  complication  of  treatment  with  heparin.  It  is  associated  with  mild-to-moderate  thrombocytopenia,  although  the  main  clinical  concern  is  the  high  frequency  of  both  arterial  and  venous  thromboembolism,  which  may  be  limb-  or  life-threatening.  HIT  is  an  immune  complex-based  disorder  involving  platelet  factor  4  complexed  to  negatively  charged  multimeric  molecules,  especially  surface  heparan  side  chains.  It  is  initiated  by  exposure  to  heparin,  particularly  unfractionated  heparin.  There  is  growing  understanding  of  the  unusual  nature  of  the  underlying  immune  response  in  HIT,  why  certain  individuals  develop  this  disorder,  and  why  HIT  is  prothrombotic.  Diagnosis  is  based  upon  an  assessment  of  clinical  probability  and  specialized  laboratory  testing.  Management  involves  immediate  cessation  of  heparin  and  initiation  of  parenteral  inhibitors  of  thrombin  or  factor  Xa.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - hemonc.mhmedical.com/content.aspx?aid=1121103190
ER  -