TY - CHAP M1 - Book, Section TI - Hemolytic Anemia Resulting from Warm-Reacting Antibodies A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Kipps, Thomas J. A1 - Prchal, Josef T. A1 - Levi, Marcel M. PY - 2011 T2 - Williams Manual of Hematology, 8e AB - In autoimmune hemolytic anemia (AHA), shortened red blood cell (RBC) survival is the result of host antibodies that react with autologous RBC.AHA may be classified by whether an underlying disease is present (secondary) or not (primary or idiopathic) (Table 24–1).AHA may also be classified by the nature of the antibody (Table 24–2)."Warm-reacting" antibodies are usually of the IgG type, have optimal activity at 37°C, and bind complement."Cold-reacting" antibodies show affinity at lower temperatures (see Chap. 25).Occasionally, mixed disorders occur with both warm and cold antibodies.Warm antibody AHA is the most common type. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/14 UR - hemonc.mhmedical.com/content.aspx?aid=1126651690 ER -