TY - CHAP M1 - Book, Section TI - Basophils and Mast Cells and Their Diseases A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Kipps, Thomas J. A1 - Prchal, Josef T. A1 - Levi, Marcel M. PY - 2011 T2 - Williams Manual of Hematology, 8e AB - Normal basophil count is 0.015 to 0.08 × 109/L.The causes of basophilia are listed in Table 35–1.An increase in the absolute basophil count among other blood cell abnormalities may be a useful sign of a chronic clonal myeloid disease (see Table 35–1).In chronic myelogenous leukemia (CML), an increased absolute basophil count occurs in virtually all patients.De novo acute basophilic leukemia is very rare, but marrow basophilia may be associated uncommonly with other subtypes of acute myelogenous or acute promyelocytic leukemia (see Table 35–2).Basophils in acute or chronic clonal myeloid diseases are derived from the malignant clone and occasionally may cause symptoms of histamine release (flushing, pruritus, hypotension) or severe peptic ulcer disease reflecting hypersecretion of gastric acid and pepsin. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/01 UR - hemonc.mhmedical.com/content.aspx?aid=1126652182 ER -