TY  - CHAP
M1  - Book, Section
TI  - Hodgkin Lymphoma
A1  - Lichtman, Marshall A.
A1  - Kaushansky, Kenneth
A1  - Kipps, Thomas J.
A1  - Prchal, Josef T.
A1  - Levi, Marcel M.
PY  - 2011
T2  - Williams Manual of Hematology, 8e
AB  - Neoplasm  of  lymphoid  tissue  in  most  cases  derived  from  germinal  center  B  cells,  defined  by  the  presence  of  the  Reed-Sternberg  cells  or  its  mononuclear  variant  Hodgkin  cells  with  a  characteristic  immunophenotype  and  appropriate  cellular  background.The  Reed-Sternberg  and  Hodgkin  cell,  the  neoplastic  cells  defining  Hodgkin  disease,  are  considered  of  B-cell  origin  based  on  its  clonal  immunoglobulin  gene  rearrangements.Classic  Hodgkin  disease  accounts  for  95  percent  of  cases  and  contains  four  histologic  subtypes  that  are  distinguished  on  the  basis  of  microscopic  appearance  and  relative  proportions  of  Reed-Sternberg  cells,  lymphocytes,  and  fibrosis:  nodular  sclerosis,  mixed  cellularity,  lymphocyte-depleted,  or  lymphocyte-rich  Hodgkin  disease.  A  fifth  subtype,  nodular  lymphocyte  predominance  has  been  added  to  the  four  classic  histologic  types  (see  Table  59–1).  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/17
UR  - hemonc.mhmedical.com/content.aspx?aid=1126653604
ER  -