TY - CHAP M1 - Book, Section TI - Antimetabolites: Nucleoside and Base Analogs A1 - Chabner, Bruce A. A2 - Chabner, Bruce A. A2 - Longo, Dan L. PY - 2016 T2 - Harrison's Manual of Oncology, 2e AB - The synthesis of new DNA is an essential step in the replication of normal and malignant cells. Accordingly, the four bases that comprise DNA (the pyrimidines: cytosine, thymine; and the purines: adenine, and guanine) have provided a rational target for synthesis of analogues that inhibit the function of DNA, including its replication. These bases become active substrates for DNA synthesis through the attachment of deoxyribose sugars to form a deoxynucleoside. Three phosphate molecules must then be attached to the 5′-OH position of the nucleoside's sugar, forming a metabolically active deoxynucleotide. These synthetic reactions, which lead to formation of the triphosphates required for making DNA, occur within the cancer cell, as well as within normal proliferating tissues, such as bone marrow and epithelium. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - hemonc.mhmedical.com/content.aspx?aid=1127646271 ER -