TY - CHAP M1 - Book, Section TI - Diffuse Large B-Cell Lymphoma A1 - Gao, Jennifer A1 - Hochberg, Ephraim Paul A2 - Chabner, Bruce A. A2 - Longo, Dan L. PY - 2016 T2 - Harrison's Manual of Oncology, 2e AB - Lymphomas are a malignancy arising from lymphoid cells, with more than 60 distinct variants identified by the World Health Organization (WHO). Lymphomas can originate in B cells, T cells, or natural killer cells, and are broadly categorized into Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). Within NHL, further differentiation is made based on clinical presentation and histology. About 85% of lymphomas in the United States and Western Europe are of B-cell origin. Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of NHL in North America and the focus of this chapter. The majority of the information in this chapter is applicable to DLBCL-NOS (not otherwise specified). Short discussions of other subtypes of diffuse large B-cell lymphoma and of other lymphomas of large B cells are included at the end of this chapter. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1127648110 ER -