TY - CHAP M1 - Book, Section TI - Heparin-Induced Thrombocytopenia A1 - Frame, James N. A1 - Bartholomew, John R. A2 - Boyiadzis, Michael M. A2 - Frame, James N. A2 - Kohler, David R. A2 - Fojo, Tito PY - 2016 T2 - Hematology-Oncology Therapy, 2e AB - Heparin-induced thrombocytopenia is a prothrombotic disorder mediated by IgG antibodies that bind to conformational epitopes on PF4 when it is complexed with heparin. Typically, the platelet counts are only moderately reduced. Occasionally patients do not have thrombocytopenia, but their platelet counts decrease by 50% from pretreatment levels Kelton JG et al. N Engl J Med 2013;368:737–744 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1128368100 ER -