TY - CHAP M1 - Book, Section TI - Monocytosis and Monocytopenia A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Prchal, Josef T. A1 - Levi, Marcel M. A1 - Burns, Linda J. A1 - Armitage, James O. PY - 2017 T2 - Williams Manual of Hematology, 9e AB - Monocytes in the blood are in transit. They function in the tissues, where they mature into macrophages and participate in:— Inflammation, including granulomatous reactions, atheroma formation, and tissue repair— Immunologic reactions, including delayed hypersensitivity— Reactions to neoplasia and allograftsThe need for macrophages in tissues also can be met by local proliferation of macrophages, not requiring increased transit of blood monocytes.Ninety percent of blood monocytes intensely express CD14 (lipopolysaccharide receptor) but not CD16 (Fc receptor) and 10% have weak expression of CD14 and strongly express CD16.Older persons have a striking decrease in the proportion of CD14++CD16– to CD14+CD16+ monocytes compared with younger persons.Disorders rarely produce abnormalities of monocytes alone in the absence of other blood cell abnormalities. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1133363604 ER -