TY - CHAP M1 - Book, Section TI - Pharmacology and Toxicity of Antineoplastic Drugs A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Prchal, Josef T. A1 - Levi, Marcel M. A1 - Burns, Linda J. A1 - Armitage, James O. PY - 2017 T2 - Williams Manual of Hematology, 9e AB - Knowledge of drug actions, clinical toxicities, pharmacokinetics, and drug interactions is essential for the safe and effective administration of cancer chemotherapy.Base treatment on evidence from clinical trials.Use established regimens and recheck doses.Choice of a particular drug treatment program should depend on the disease, histology, and stage of the disease and on an assessment of individual patient tolerance.High-dose chemotherapy programs used in autologous and allogeneic hematopoietic cell transplantation result in additional organ toxicities that are not seen at conventional doses.Chemotherapy often targets process of DNA replication.More recently, drugs have been introduced to target specific cellular processes, including receptor signaling, inhibition of oncoproteins, angiogenesis, and membrane cluster of differentiation antigens. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - hemonc.mhmedical.com/content.aspx?aid=1133363834 ER -