TY  - CHAP
M1  - Book, Section
TI  - Primary Myelofibrosis
A1  - Lichtman, Marshall A.
A1  - Kaushansky, Kenneth
A1  - Prchal, Josef T.
A1  - Levi, Marcel M.
A1  - Burns, Linda J.
A1  - Armitage, James O.
PY  - 2017
T2  - Williams Manual of Hematology, 9e
AB  - Primary  myelofibrosis  is  a  chronic  myeloid  neoplasm  that  originates  in  mutations  in  a  multipotential  hematopoietic  cell,  possibly  the  lymphohematopoietic  stem  cell.  The  disease  is  characterized  by  (1)  anemia;  (2)  splenomegaly;  (3)  increased  CD34+  cells,  immature  granulocytes,  erythroid  precursors,  and  teardrop-shaped  red  cells  in  the  blood;  (4)  increased  dysmorphic  megakaryocytes,  the  cytokines  from  which  induce  marrow  fibrosis;  and  (5)  osteosclerosis.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - hemonc.mhmedical.com/content.aspx?aid=1133364284
ER  -