TY - CHAP M1 - Book, Section TI - The Surgical Management of Locoregionally Recurrent and in-Transit Melanoma A1 - Zager, Jonathan S. A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. PY - 2018 T2 - Textbook of Complex General Surgical Oncology AB - Locoregional recurrence of a melanoma is defined as recurrence in or around a scar from previous melanoma surgery, or satellite or in-transit metastases. The American Joint Committee on Cancer (AJCC) groups the latter two (satellites and in-transit recurrences) in the most recent edition of the melanoma staging manual (AJCC 7th edition) as a component of nodal (N) staging.1 Satellite metastases, considered intralymphatic extensions of the primary tumor, are defined as occurring within 2 cm of the primary tumor, whereas in-transit metastases are defined as any dermal or subcutaneous metastases 2 cm or more from the primary tumor but not beyond the draining regional node basin.1 Although satellite metastases and local recurrences are often confused in clinical practice, a true local recurrence is a lesion within or very close to the scar from previous definitive surgery, whereas satellite metastases are somewhat removed from the scar but within 2 cm. The bottom line in the management of all locoregional recurrences, however, is that the treatment algorithms are usually the same. Nevertheless, these patients should be discussed in a multidisciplinary tumor board setting whenever possible. Treatment options for locoregionally recurrent melanoma include surgical resection, local intra-tumoral injections, hyperthermic isolated limb perfusion (HILP), isolated limb infusion (ILI), topical therapies, laser ablation, radiation therapy, and systemic therapies.2 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1145756028 ER -