TY - CHAP M1 - Book, Section TI - Adrenocortical Cancer A1 - Lee, Wayne S. A1 - Shen, Wen T. A1 - Duh, Quan-Yang A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. PY - 2018 T2 - Textbook of Complex General Surgical Oncology AB - Adrenocortical carcinoma (ACC) is a rare but often aggressive endocrine malignancy that may present with symptoms of hormone secretion, as a symptomatic nonfunctional abdominal mass, or as an incidental imaging finding. The first known successful adrenal cancer resection was performed by Knowsley Thornton in 1890.1,2 In the same year, Otto Ramsay published a small case series of patients with malignant adrenal tumors.3 However, prognosis was poor as tumor excision offered only temporarily relief with the majority of patients suffering from severe adrenal insufficiency. In 1949, discovery of cortisone, derived from an adrenocortical extract developed by the Mayo group, significantly improved survival from adrenalectomy.4 Other milestones include the introduction of mitotane, a pesticide derivative, which was first used in 1960 to treat inoperable or recurrent ACC.5 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/11 UR - hemonc.mhmedical.com/content.aspx?aid=1145758050 ER -