TY - CHAP M1 - Book, Section TI - Landmark Clinical Trials that Impacted Surgical Management of Invasive and Noninvasive Breast Cancer A1 - Tower, Amelia A1 - Robin, Julieta A1 - Duggal, Shivani A1 - Julian, Thomas B. A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. PY - 2018 T2 - Textbook of Complex General Surgical Oncology AB - Over the last four decades, there has been a paradigm shift in the management of breast cancer as a result of several landmark clinical trials conducted in the United States and Europe that are responsible for the new standards of breast cancer care worldwide. Advances from these clinical trials transformed the treatment of breast cancer by advocating less radical surgery and introducing the use of innovative techniques in conjunction with other modalities including systemic chemotherapy, endocrine therapy, and radiotherapy (RT). This subsequently led to a multidisciplinary approach to breast cancer and is further leading to individualized treatment for each patient. This chapter provides a review of the significant landmark clinical trials that revolutionized the management and that currently guide the surgical practice of noninvasive and invasive breast cancer. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1145759781 ER -