TY - CHAP M1 - Book, Section TI - Immunosuppressants and Tolerogens A1 - Krensky, Alan M. A1 - Azzi, Jamil R. A1 - Hafler, David A. A2 - Brunton, Laurence L. A2 - Hilal-Dandan, Randa A2 - Knollmann, Björn C. PY - 2017 T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e AB - This chapter reviews the components of the immune response and drugs that modulate immunity via immunosuppression or tolerance. Four major classes of immunosuppressive drugs are discussed: glucocorticoids (see Chapter 46), calcineurin inhibitors, antiproliferative and antimetabolic agents (see Chapter 66), and antibodies. While there are similarities, the approach to the use of immunosuppressant drugs in transplant rejection has evolved separately from the approaches used to treat autoimmune disease and thus is presented separately. Finally, the chapter ends with a brief case study of immunotherapy for the autoimmune disease MS. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1162539782 ER -