TY - CHAP M1 - Book, Section TI - Penicillins, Cephalosporins, and Other β-Lactam Antibiotics A1 - MacDougall, Conan A2 - Brunton, Laurence L. A2 - Hilal-Dandan, Randa A2 - Knollmann, Björn C. PY - 2017 T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e AB - The β-lactam antibiotics—penicillins, cephalosporins, carbapenems, and monobactams—share a common structure (β-lactam ring) and mechanism of action (i.e., inhibition of the synthesis of the bacterial peptidoglycan cell wall). Bacterial resistance against the β-lactam antibiotics continues to increase at a dramatic rate. β-Lactamase inhibitors such as clavulanate and avibactam can extend the utility of these antibiotics against β-lactamase–producing organisms. Unfortunately, resistance includes not only production of β-lactamases but also alterations in the bacterial enzymes targeted by β-lactam antibiotics, as well as decreased entry or active efflux of the antibiotic. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1162544617 ER -