TY - CHAP M1 - Book, Section TI - Preface A1 - Press, Oliver W. A1 - Lichtman, Marshall A. A1 - Leonard, John P. PY - 2017 T2 - Williams Hematology Malignant Lymphoid Diseases AB - Bifurcation is an essential feature of biology. It underlies differentiation as one cell, through a process of mitosis accompanied by altered gene expression, forms two distinct cell lineages. The hematopoietic system is a dramatic example of this phenomenon. A single lymphohematopoietic stem cell, can over the course of several bifurcations, differentiate and then mature into at least 11 unique functional cells. In some cases, these cells can mature further into different phenotypes influenced by the environment in which they reside. Consider, for example, the monocytes, Kupffer cells, osteoclasts, microglia, and alveolar macrophages. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1148367598 ER -