TY - CHAP M1 - Book, Section TI - Dendritic Cells and Adaptive Immunity A1 - Dhodapkar, Madhav V. A1 - Banchereau, Jacques A2 - Kaushansky, Kenneth A2 - Prchal, Josef T. A2 - Burns, Linda J. A2 - Lichtman, Marshall A. A2 - Levi, Marcel A2 - Linch, David C. PY - 2021 T2 - Williams Hematology, 10e AB - SUMMARYDendritic cells (DCs) are a multifunctional group of cells that serve as sentinels of the immune system and thus regulate many immune functions. DCs play a central role in initiating adaptive immune responses to pathogens and initiating antitumor immune responses. DC receptors sense environmental stimuli and can respond rapidly to both foreign pathogens and danger signals derived from tissue damage or immune complexes. Through their capacity to present antigen to T cells in immune-activating or immune-dampening contexts, DCs can both induce T-cell proliferation (activation) or lack of activation (tolerance). In this way, DCs help regulate immune responses mediated by T cells and B cells of the adaptive immune system. This chapter describes the varied types and functions of this important class of cells. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1178737663 ER -