TY  - CHAP
M1  - Book, Section
TI  - Tumor Growth, Microenvironment, Metabolism, and Hypoxia
A1  - Dhani, Neesha
A1  - Hill, Richard P.
A1  - Tannock, Ian F.
A2  - Harrington, Lea A.
A2  - Tannock, Ian F.
A2  - Hill, Richard P.
A2  - Cescon, David W.
PY  - 2021
T2  - The Basic Science of Oncology, 6e
AB  - Tumors  grow  because  the  homeostatic  mechanisms  that  maintain  the  appropriate  number  of  cells  in  normal  tissues  are  defective,  leading  to  an  imbalance  between  cell  proliferation  and  cell  death  and  to  expansion  of  the  cell  population.  Methods  based  on  autoradiography  with  tritiated  thymidine  in  the  1950s  and  1960s,  and  the  subsequent  application  of  flow  cytometry,  have  allowed  a  detailed  analysis  of  tumor  growth  in  terms  of  the  kinetics  of  proliferation  of  the  constituent  cells.  The  proliferative  rate  of  tumor  cells  varies  widely  between  tumors;  slowly  proliferating  or  nonproliferating  cells  are  common,  and  there  is  often  a  high  rate  of  cell  death.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/17
UR  - hemonc.mhmedical.com/content.aspx?aid=1179324690
ER  -