TY - CHAP M1 - Book, Section TI - Cardiac Complications A1 - Sachdev, Vandana A1 - Malik, Punam A1 - Wood, John A1 - Detterich, Jon A2 - Gladwin, Mark T. A2 - Kato, Gregory J. A2 - Novelli, Enrico M. PY - 2021 T2 - Sickle Cell Disease AB - The heart, lungs, and blood vessels represent an integrally coupled system. Sickle cell disease (SCD) is characterized by a diffuse, progressive vascular disease that not only directly damages cardiac microvasculature but also places abnormal mechanical stressors on the heart by increasing preload (anemia) and afterload (peripheral and pulmonary vascular damage). The heart may also be damaged by the sequelae of treatments for SCD, such as chronic transfusions. In this section, we focus on how the primary vascular physiology described in earlier sections impacts the integrated cardiovascular system. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/11 UR - hemonc.mhmedical.com/content.aspx?aid=1179344262 ER -