TY  - CHAP
M1  - Book, Section
TI  - Cardiac Complications
A1  - Sachdev, Vandana
A1  - Malik, Punam
A1  - Wood, John
A1  - Detterich, Jon
A2  - Gladwin, Mark T.
A2  - Kato, Gregory J.
A2  - Novelli, Enrico M.
PY  - 2021
T2  - Sickle Cell Disease
AB  - The  heart,  lungs,  and  blood  vessels  represent  an  integrally  coupled  system.  Sickle  cell  disease  (SCD)  is  characterized  by  a  diffuse,  progressive  vascular  disease  that  not  only  directly  damages  cardiac  microvasculature  but  also  places  abnormal  mechanical  stressors  on  the  heart  by  increasing  preload  (anemia)  and  afterload  (peripheral  and  pulmonary  vascular  damage).  The  heart  may  also  be  damaged  by  the  sequelae  of  treatments  for  SCD,  such  as  chronic  transfusions.  In  this  section,  we  focus  on  how  the  primary  vascular  physiology  described  in  earlier  sections  impacts  the  integrated  cardiovascular  system.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/23
UR  - hemonc.mhmedical.com/content.aspx?aid=1179344262
ER  -