TY - CHAP M1 - Book, Section TI - Alternative Donor Transplants: Cord Blood Transplant A1 - Rafei, Hind A1 - Olson, Amanda A1 - Mehta, Rohtesh S. A1 - Oran, Betul A1 - Rezvani, Katayoun A1 - Shpall, Elizabeth J. A2 - Kantarjian, Hagop M. A2 - Wolff, Robert A. A2 - Rieber, Alyssa G. PY - 2022 T2 - The MD Anderson Manual of Medical Oncology, 4e AB - KEY CONCEPTSCord blood is a valuable alternative donor source for stem cell transplant, offering a number of advantages: ease of collection, availability for urgent need, less stringent human leukocyte antigen (HLA)-matching requirement, and lower risk of graft-versus-host disease.Data are evolving about the difference in outcomes of stem cell transplant using different graft sources, but more recent data suggest that there is no survival advantage of a matched unrelated graft over cord blood.To overcome the limitation of low cell doses in single cord blood units, double cord blood transplant has been adopted for many patients.High-intensity myeloablative regimens are used in young and fit patients, whereas reduced-intensity regimens are used in older or unfit patients.Infections are the leading cause of early nonrelapse mortality after cord blood transplant, and graft-versus-host disease is the leading cause of late mortality.Novel strategies to improve cord blood transplant outcomes include improving cell collection, homing and engraftment, ex vivo expansion, and in vivo enhancement. SN - PB - McGraw Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1190834033 ER -