TY - CHAP M1 - Book, Section TI - Disseminated Intravascular Coagulation A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Prchal, Josef T. A1 - Levi, Marcel M. A1 - Burns, Linda J. A1 - Linch, David C. PY - 2022 T2 - Williams Manual of Hematology, 10e AB - Disseminated intravascular coagulation (DIC) is a syndrome that is characterized by systemic intravascular activation of coagulation, leading to fibrin deposition in the microvasculature and small and mid-size vessels, thereby contributing to organ dysfunction. Simultaneously, ongoing consumption of platelets and coagulation factors leads to thrombocytopenia and impaired coagulation and may result in serious bleeding complications.DIC never occurs by itself but is always secondary to an underlying cause. Table 86–1 lists the most frequently occurring disorders know to be associated with DIC. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/14 UR - hemonc.mhmedical.com/content.aspx?aid=1189336645 ER -