TY - CHAP M1 - Book, Section TI - Drug Metabolism A1 - Gonzalez, Frank J. A1 - Coughtrie, Michael A2 - Brunton, Laurence L. A2 - Knollmann, Björn C. PY - 2023 T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition AB - AbbreviationsADR: adverse drug reactionAHR: aryl hydrocarbon receptorAUC: area under the plasma concentration–time curveCAR: constitutive androstane receptorCYP: cytochrome P450EH: epoxide hydrolaseER: endoplasmic reticulumFMO: flavin-containing monooxygenaseGI: gastrointestinalGSH and GSSG: reduced and oxidized glutathioneGST: glutathione-S-transferaseHGPRT: hypoxanthine guanine phosphoribosyl transferaseHIF: hypoxia-inducible factorHIV: human immunodeficiency virusINH: isonicotinic acid hydrazide (isoniazid)MAPK: mitogen-activated protein kinasemEH: microsomal epoxide hydrolase6-MP: 6-mercaptopurineMT: methyltransferaseNADPH: nicotinamide adenine dinucleotide phosphateNAPQI:N-acetyl-p-benzoquinone imineNAT:N-acetyltransferasePAPS: 3′-phosphoadenosine-5′-phosphosulfatePPAR: peroxisome proliferator–activated receptorPXR: pregnane X receptorSULT: sulfotransferaseTPMT: thiopurine methyltransferaseUDP-GA: uridine diphosphate–glucuronic acidUGT: uridine diphosphate–glucuronosyltransferase SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/04 UR - hemonc.mhmedical.com/content.aspx?aid=1193227030 ER -