TY - CHAP M1 - Book, Section TI - Antiretroviral Agents and Treatment of HIV Infection A1 - Flexner, Charles W. A2 - Brunton, Laurence L. A2 - Knollmann, Björn C. PY - 2023 T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition AB - Safe and effective pharmacotherapy to treat and prevent human immunodeficiency virus (HIV) is one of the greatest achievements of science and public health in the past century. Infected individuals who maintain a daily oral regimen now have a normal or near-normal life expectancy. More than 30 approved drugs and dozens of formulations have produced thousands of possible drug combinations, but most patients receive one of a handful of well-tolerated and rigorously tested regimens. Unique features of antiretroviral therapy include the need for lifelong treatment to control virus replication and the possibility of rapid emergence of permanent drug resistance if these agents are not used properly. Although three-drug and two-drug combination oral regimens have radically altered the course of this epidemic, future options will include long-acting injectable and implantable formulations. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1193240488 ER -