TY - CHAP M1 - Book, Section TI - Environmental Toxicology A1 - Ehrlich, Allison K. A2 - Brunton, Laurence L. A2 - Knollmann, Björn C. PY - 2023 T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition AB - Humans are exposed to chemicals from their environment on a daily basis. Fortunately, mammals have evolved mechanisms to protect themselves from toxic effects of many exogenous chemicals, including the xenobiotic transport and metabolic mechanisms described in Chapters 4 to 7. While the human body is relatively well adapted to deal with xenobiotics, there are situations in which such environmental agents may cause significant toxicity. The Industrial Revolution and the development of chemical industries have increased human exposures to chemicals that were previously infrequent or absent. Concern about environmental toxicants has stimulated interest and research in environmental toxicology, the study of how chemicals in our environment adversely affect human health; and in occupational toxicology, the study of how chemicals in the workplace affect human health. Many authoritative textbooks are available in these areas. This chapter does not attempt a thorough coverage; rather, it sets forth a few basic principles, discusses carcinogens and chemoprevention and heavy metal intoxication and chelation therapy, and provides an overview of endocrine disruptors and immunotoxicants. The chapter concludes with emerging data on how microbiome-mediated metabolism contributes to xenobiotic biotransformation and toxicity. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1193243843 ER -