TY  - CHAP
M1  - Book, Section
TI  - Protein Kinase Inhibitors and Pathway-Targeted Small Molecules
A1  - Wellstein, Anton
A1  - Giaccone, Giuseppe
A2  - Brunton, Laurence L.
A2  - Knollmann, Björn C.
PY  - 2023
T2  - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition
AB  - AbbreviationsABC:  ATP-binding  cassetteABL:  Abelson  murine  leukemia  viral  oncogene  homologALK:  anaplastic  lymphoma  kinaseALL:  acute  lymphoblastic  leukemiaAML:  acute  myelocytic  leukemiaAPML:  acute  promyelocytic  leukemiaARNT:  aryl  hydrocarbon  receptor  nuclear  translocator  (also  known  as  HIF-1β)ATO:  arsenic  trioxideAUC:  area  under  the  curveBCC:  basal  cell  carcinomaBCL:  B-cell  lymphomaBCR:  breakpoint  cluster  region  (chr22)BCRP:  breast  cancer  resistance  proteinBH:  BCL2  homology  domainBIM:  BCL2-like  protein  11BRCA:  breast  cancer  susceptibility  geneBRK:  breast  tumor  kinase,  PTK6BTK:  Bruton  tyrosine  kinaseCDK:  cyclin-dependent  kinaseCLL:  chronic  lymphocytic  leukemiaCML:  chronic  myelocytic  leukemiaCRL4-CRBN:  cullin-RING  ubiquitin  ligase  cereblon  complexcuSCC:  cutaneous  squamous  cell  carcinomaCXCR4:  C-X-C  chemokine  receptor  4DNMT:  DNA  methyltransferaseECG:  electrocardiogramEGF(R):  epidermal  growth  factor  (receptor)  =  HER1EML4:  echinoderm  microtubule-associated  protein-like  4ER:  estrogen  receptorERK:  extracellular  signal-related  kinase  =  MAPKFGF(R):  fibroblast  growth  factor  (receptor)FIP1L1:  factor  interacting  with  poly  (A)  polymeraseFKBP12:  immunophilin-binding  protein  for  tacrolimus  (FK506)FL:  follicular  B-cell  non-Hodgkin  lymphomaFLT(1  or  4):  fms-related  tyrosine  kinase  (1  or  4)  (=  VEGFR1  or  3)FMO3:  flavin  containing  monooxygenase  3GI:  gastrointestinalGIST:  gastrointestinal  stromal  tumorHDAC:  histone  deacetylaseHER1/2:  human  epidermal  growth  factor  receptor;  1  =  EGFR;  2  =  erbB22-HG:  2-hydroxyglutarateHGF(R):  hepatocyte  growth  factor  (receptor)  =  cMETHIF-1  or  -2:  hypoxia-inducible  factor  1  or  2HMT:  histone  methyltransferaseHSC:  hematopoietic  stem  cellIFN:  interferonIGF1R:  insulin-like  growth  factor  1  receptorIκB:  inhibitor  of  nuclear  factor  kappa  BIL:  interleukinIMiDs:  immunomodulatory  imide  drugs  (e.g.,  thalidomide)ITK:  inducible  T-cell  kinaseKDR:  kinase  insert  domain  receptor  =  VEGFR2KIT:  feline  sarcoma  virus  oncogene  homologLCK:  lymphocyte-specific  kinaseMAPK:  mitogen-activated  extracellular  signal  regulated  protein  kinase  =  ERKMCL:  mantle  cell  lymphomaMCyR:  major  cytogenetic  responseMDS:  myelodysplastic  syndromeMEK:  mitogen-activated  extracellular  signal  regulated  protein  kinase  kinase  =  MKKMET:  mesenchymal-epithelial  transition  factor  (=  HGFR)MM:  multiple  myelomamTOR:  mammalian  or  mechanistic  target  of  rapamycinNCCN:  National  Comprehensive  Cancer  NetworkNET:  neuroendocrine  tumorNF-κB:  nuclear  factor-κBNK:  natural  killerNPM:  nucleophosmin  (gene)NRAS:  neuroblastoma  RAS  virus  homologNSCLC:  non–small  cell  lung  cancerOATP:  organic  anion-transporting  polypeptidePARP:  poly(ADP-ribose)  polymerasePDGF(R):  platelet-derived  growth  factor  (receptor)Pgp:  P-glycoproteinPI3K:  phosphatidylinositol  3-kinasePIK3CA:  PI3K  catalytic  subunit  α  gene;  codes  for  the  p110α  enzymePIP2:  phosphatidylinositol  4,5-bisphosphatePIP3:  phosphatidylinositol  (3,4,5)-trisphosphatePNET:  peripheral  neuroendocrine  tumorPPES:  palmar-plantar  erythrodysesthesia  syndromePPI:  proton  pump  inhibitorPROTAC:  proteolysis-targeting  chimeraPTEN:  phosphatase  and  tensin  homologRb:  retinoblastoma  (protein)RCC:  renal  cell  carcinomaRET:  “rearranged  during  transfection”  receptor  tyrosine  kinaseROS1:  orphan  receptor  tyrosine  kinaseSDF:  stromal  cell-derived  factorSLL:  small  lymphocytic  lymphomaTGF:  transforming  growth  factorTIE:  tyrosine  kinase  with  Ig  and  EGF  domainsTKI:  tyrosine  kinase  inhibitorTSC:  tuberous  sclerosis  complexVEGF(R):  vascular  endothelial  growth  factor  (receptor)VHL:  von  Hippel-Lindau  (pVHL  =  VHL  protein)  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - hemonc.mhmedical.com/content.aspx?aid=1193242501
ER  -