TY - CHAP M1 - Book, Section TI - The Organization and Structure of Lymphoid Tissues A1 - Freud, Aharon G. A1 - Caligiuri, Michael A. A2 - Kaushansky, Kenneth A2 - Lichtman, Marshall A. A2 - Prchal, Josef T. A2 - Levi, Marcel M. A2 - Press, Oliver W. A2 - Burns, Linda J. A2 - Caligiuri, Michael PY - 2015 T2 - Williams Hematology, 9e AB - SUMMARYThe lymphoid tissues can be divided into primary and secondary lymphoid organs.* Primary lymphoid tissues are sites where lymphocytes develop from progenitor cells into functional and mature lymphocytes. The major primary lymphoid tissue is the marrow, the site where all lymphocyte progenitor cells reside and initially differentiate. This organ is discussed in Chap. 5. The other primary lymphoid tissue is the thymus, the site where progenitor cells derived from the marrow differentiate into mature thymus-derived (T) cells. Secondary lymphoid tissues are sites where lymphocytes undergo additional maturation and also interact with each other and with nonlymphoid cells to generate immune responses to antigens. These tissues include the spleen, lymph nodes, and mucosa-associated lymphoid tissues such as tonsils. The structure of these tissues provides insight into how the immune system discriminates between self-antigens and foreign antigens and develops the capacity to orchestrate a variety of specific and nonspecific defenses against invading pathogens. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/12/07 UR - hemonc.mhmedical.com/content.aspx?aid=1121088799 ER -