TY - CHAP M1 - Book, Section TI - Erythrocyte Antigens and Antibodies A1 - Reid, Marion E. A1 - Lomas-Francis, Christine A2 - Kaushansky, Kenneth A2 - Lichtman, Marshall A. A2 - Prchal, Josef T. A2 - Levi, Marcel M. A2 - Press, Oliver W. A2 - Burns, Linda J. A2 - Caligiuri, Michael Y1 - 2015 N1 - T2 - Williams Hematology, 9e AB - SUMMARYBlood group antigens are structures on the outer surface of human red blood cells (RBCs) that can be recognized by the immune system of individuals who lack that particular structure. Identification of RBC antigens and antibodies has been the basis of pretransfusion compatibility testing and the safe transfusion practices used today and also can provide insights into understanding the etiology of hemolytic disease of the fetus and the newborn. Biochemical and molecular studies have led to definition of the biologic functions of molecules expressing blood group antigens. These molecules play a critical role in susceptibility to infection by malarial parasites, some viruses, and bacteria. Alteration of RBC antigen expression is associated with many molecular backgrounds and some play a role in the clinical manifestations of certain diseases. Erythrocytes, far from being inert containers of hemoglobin, are active in a variety of physiologic processes. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - hemonc.mhmedical.com/content.aspx?aid=1121105695 ER -