TY - CHAP M1 - Book, Section TI - Microangiopathic Hemolytic Anemia A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Kipps, Thomas J. A1 - Prchal, Josef T. A1 - Levi, Marcel M. Y1 - 2011 N1 - T2 - Williams Manual of Hematology, 8e AB - Intravascular hemolysis caused by fragmentation of normal red cells passing through abnormal arterioles and other small vessels.The hemolytic anemia generated by red cell damage in small vessels is referred to as microangiopathic hemolytic anemia, a type of fragmentation hemolytic anemia."Split" red cells of varying shapes, referred to as schistocytes, are prominent on blood films.Less-extensive red cell fragmentation, development of schistocytes, and hemolysis may also occur under conditions of more moderate vascular occlusion or endothelial surface abnormalities, sometimes under conditions of lower shear stress.Excessive platelet aggregation, fibrin polymer formation, and secondary fibrinolysis in the arterial or venous microcirculation are seen in disseminated intravascular coagulation (see Chap. 86), preeclampsia, giant cavernous hemangiomas (the Kasabach-Merritt phenomenon), or in the HELLP (hemolysis elevated liver enzyme and low platelets) syndrome. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - hemonc.mhmedical.com/content.aspx?aid=1126651599 ER -