TY  - CHAP
M1  - Book, Section
TI  - The Acute Lymphocytic Leukemias
A1  - Lichtman, Marshall A.
A1  - Kaushansky, Kenneth
A1  - Kipps, Thomas J.
A1  - Prchal, Josef T.
A1  - Levi, Marcel M.
Y1  - 2011
N1  - 
T2  - Williams Manual of Hematology, 8e
AB  - Acute  lymphocytic  (syn.  lymphoblastic)  leukemia  (ALL)  is  a  neoplastic  disease  of  immature  lymphocytes  or  lymphocyte  progenitor  cells  of  either  the  B-  or  T-cell  lineage.The  immune  phenotype  of  the  leukemia  cells  reflects  the  cell-lineage  and  differentiation  stage  of  the  transformed  clone.At  diagnosis  the  leukemia  cells  typically  have  replaced  normal  cells  in  the  marrow  and  have  disseminated  to  various  extramedullary  sites,  accounting  for  many  of  the  clinical  manifestations.Treatment  of  ALL  has  progressed  incrementally,  beginning  with  the  development  of  effective  therapy  for  central  nervous  system  (CNS)  disease,  followed  by  intensification  of  early  treatment.Based  on  National  Cancer  Institute  statistics,  patients  with  ALL  <45  years  of  age  have  a  5-year  survival  of  75  percent,  which  is  heavily  influenced  by  the  approximately  80  percent  cure  rate  in  children  with  the  disease.  The  5-year  survival  is  approximately  25  percent  in  the  age  group  45  to  54  and  decreases  in  each  succeeding  decade  to  approximately  6  percent  in  patients  over  65  years.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/23
UR  - hemonc.mhmedical.com/content.aspx?aid=1126653275
ER  -