TY - CHAP M1 - Book, Section TI - The Chronic Lymphocytic Leukemias A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Kipps, Thomas J. A1 - Prchal, Josef T. A1 - Levi, Marcel M. Y1 - 2011 N1 - T2 - Williams Manual of Hematology, 8e AB - Chronic lymphocytic leukemia (CLL) is a neoplastic disease characterized by accumulation of small, mature-appearing lymphocytes in blood, marrow, and lymphoid tissues.The most prevalent adult leukemia in western societies.The age-adjusted incidence rate for CLL in the United States is 4.2/100,000 persons according to the Surveillance Epidemiology and End-Result Program of the National Cancer Institute.The age-adjusted incidence rate of CLL worldwide is 2.5/100,000 persons as determined by the International Agency for Research on Cancer of the World Health Organization.In 98 percent of patients, the disease is of B-cell lineage; less than 2 percent of patients have T-cell lineage leukemia.Approximately 0.8 percent of all cancers and approximately 30 percent of all leukemias annually.CLL is very uncommon in Eastern Asia (e.g., Japan and Korea). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - hemonc.mhmedical.com/content.aspx?aid=1126653505 ER -