TY  - CHAP
M1  - Book, Section
TI  - Myeloma
A1  - Lichtman, Marshall A.
A1  - Kaushansky, Kenneth
A1  - Kipps, Thomas J.
A1  - Prchal, Josef T.
A1  - Levi, Marcel M.
Y1  - 2011
N1  - 
T2  - Williams Manual of Hematology, 8e
AB  - Myeloma  is  a  malignancy  of  terminally  differentiated  B  cells  (plasma  cells)  that  produces  a  complete  and/or  partial  (light  chain)  monoclonal  immunoglobulin  protein.Clinical  and  laboratory  manifestations  are  heterogeneous,  but  typically  include:—  A  monoclonal  immunoglobulin  in  plasma  and/or  monoclonal  light  chains  in  plasma  and  urine.  In  rare  cases,  the  cells  do  not  secrete  a  monoclonal  protein  in  the  plasma.—  Decreased  polyclonal  immunoglobulin  secretion  by  residual  normal  plasma  cells,  which  predispose  to  infections.—  Myeloma  cell  proliferation  in  marrow  leading  to  impaired  hematopoiesis.—  Osteolytic  bone  disease.—  Often  hypercalcemia  as  a  result  of  osteolysis.—  Sometimes  renal  dysfunction  as  a  result  light  chain  casts  or  hypercalcemia.Nearly  85  percent  of  newly  diagnosed  myeloma  patients  who  have  gene-expression-defined  good-risk  disease  fare  so  well  with  therapy  that  the  prospect  of  cure  now  appears  tenable.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - hemonc.mhmedical.com/content.aspx?aid=1126653975
ER  -