TY - CHAP M1 - Book, Section TI - T-Cell Lymphomas A1 - Chihara, Dai A1 - Wang, Casey A1 - Duvic, Madeleine A1 - Medeiros, L. Jeffrey A1 - Oki, Yasuhiro A2 - Kantarjian, Hagop M. A2 - Wolff, Robert A. Y1 - 2016 N1 - T2 - The MD Anderson Manual of Medical Oncology, 3e AB - Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of lymphomas derived from a mature T cell (Fig. 9-1). Currently, the World Health Organization (WHO) classification combines mature T- and natural killer (NK)-cell neoplasms under the umbrella term PTCL, and the category is composed of 23 different entities (Table 9-1), based on the different morphologic, phenotypic, molecular, and clinical features, including disease site (1). Most PTCLs lack distinct genetic or biologic alterations that are seen in B-cell lymphomas, such as t(14;18) in follicular lymphoma and t(11;14) in mantle cell lymphoma. Compared with B-cell lymphomas, many types of PTCL develop not in lymph nodes, but in specific extranodal sites such as extranodal NK/T-cell lymphoma, nasal type (ENKL) in the nasal cavity, enteropathy-associated T-cell lymphoma (EATL) in the small intestine, and hepatosplenic T-cell lymphoma (HSTL) in the liver and spleen. SN - PB - McGraw-Hill Medical CY - New York, NY Y2 - 2024/10/07 UR - hemonc.mhmedical.com/content.aspx?aid=1126740719 ER -