TY  - CHAP
M1  - Book, Section
TI  - Topoisomerase Inhibitors: Camptothecins, Anthracyclines, and Etoposide
A1  - Chabner, Bruce A.
A2  - Chabner, Bruce A.
A2  - Longo, Dan L.
Y1  - 2016
N1  - 
T2  - Harrison's Manual of Oncology, 2e
AB  - Topoisomerases  carry  out  the  important  function  of  unwinding  DNA  by  creating  temporary  breaks  in  DNA,  promoting  passage  of  single  strands  of  DNA  through  breaks,  and  then  resealing  the  breaks.  This  function  is  critical  in  allowing  access  of  repair  and  replication  complexes  to  linear  strands  of  DNA.  Similar  enzymes  are  found  throughout  the  eukaryotic  and  prokaryotic  world,  a  testament  to  their  essential  function.  Likewise,  they  are  one  of  the  most  common  targets  of  naturally  occurring  poisons.  Two  classes  of  topoisomerases  (topos)  are  found  in  human  cells:  topo  I  does  not  require  ATP  for  strand  breakage  and  resealing,  and  creates  single  strand  breaks,  while  the  several  isoforms  of  topo  II  require  ATP  and  create  double  strand  breaks.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - hemonc.mhmedical.com/content.aspx?aid=1127646436
ER  -