TY  - CHAP
M1  - Book, Section
TI  - Differentiating Agents
A1  - Chabner, Bruce A.
A2  - Chabner, Bruce A.
A2  - Longo, Dan L.
Y1  - 2016
N1  - 
T2  - Harrison's Manual of Oncology, 2e
AB  - An  obvious  feature  of  malignant  cells  is  their  failure  to  differentiate,  and  to  acquire  the  histologic,  biochemical,  and  functional  features  of  the  mature  cells  of  the  tissue  from  which  they  arise.  Thus,  leukemia  cells  resemble  in  appearance,  surface  markers,  and  molecular  profile  the  more  primitive  normal  progenitors  of  the  myeloid  or  lymphoid  series.  Indeed  it  has  been  possible  to  isolate  a  small  fraction  of  continuously  self-renewing  cells  (called  tumor  stem  cells)  from  frankly  malignant  tissues.  These  tumor  cells  are  able  to  reproduce  multiple  differentiated  cell  lineages  when  appropriately  stimulated  by  "differentiating"  agents  such  as  5-azacytidine  (see  Chapter  1)  or  retinoids.  The  progression  from  mature  cell  phenotype  to  an  undifferentiated  malignancy  is  recapitulated  in  serial  observations  of  chronic  myelogenous  leukemia  and  in  experimental  models  of  malignant  transformation.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - hemonc.mhmedical.com/content.aspx?aid=1127646605
ER  -