TY - CHAP M1 - Book, Section TI - Antiandrogen Therapy A1 - Chabner, Bruce A. A2 - Chabner, Bruce A. A2 - Longo, Dan L. Y1 - 2016 N1 - T2 - Harrison's Manual of Oncology, 2e AB - The initial attempt at treating cancer with hormone ablation was implemented by Charles Huggins at the University of Chicago in 194l, when he hypothesized that the prostate depended on testosterone (and, ultimately, its metabolite dihydrotestosterone) for its growth (1). Orchiectomy of patients with advanced prostate cancer reduced serum testosterone to barely detectable levels (less than 50 ng/dl) and produced dramatic relief of bone pain in 90% of such patients. The median duration of response was about 1 year, and hormone-independent tumor emerged in most cases. Huggins was awarded a Nobel Prize for his work. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/09 UR - hemonc.mhmedical.com/content.aspx?aid=1127646836 ER -