TY - CHAP M1 - Book, Section TI - Folate, Cobalamin, and Megaloblastic Anemias A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Prchal, Josef T. A1 - Levi, Marcel M. A1 - Burns, Linda J. A1 - Armitage, James O. Y1 - 2017 N1 - T2 - Williams Manual of Hematology, 9e AB - These disorders are caused by impaired synthesis of DNA.They most commonly result from folate or cobalamin (vitamin B12) deficiency.Characteristics are megaloblastic cells, typically present in the erythroid series as large cells with immature-appearing nuclei but with increasing hemoglobinization of the cytoplasm—often referred to as nuclear-cytoplasmic asynchrony.Megaloblastic granulocytic cells have large size. Giant band neutrophils are a feature in the marrow with hypersegmented neutrophils in the marrow and blood. Megakaryocytes may be abnormally large with nuclear abnormalities. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - hemonc.mhmedical.com/content.aspx?aid=1133362479 ER -