TY - CHAP M1 - Book, Section TI - Hemolytic Anemia Resulting from Warm-Reacting Antibodies A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Prchal, Josef T. A1 - Levi, Marcel M. A1 - Burns, Linda J. A1 - Armitage, James O. Y1 - 2017 N1 - T2 - Williams Manual of Hematology, 9e AB - In autoimmune hemolytic anemia (AHA), shortened red blood cell (RBC) survival is the result of host antibodies that react with autologous RBC.AHA may be classified by whether an underlying disease is present (secondary) or not (primary or idiopathic) (Table 22–1).AHA may also be classified by the nature of the antibody (Table 22–2).“Warm-reacting” antibodies are usually of the immunoglobulin G (IgG) type, have optimal activity at 37°C, and bind complement.“Cold-reacting” antibodies show affinity at lower temperatures (see Chap. 23).Occasionally, mixed disorders occur with both warm and cold antibodies.Warm antibody AHA is the most common type. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2025/07/10 UR - hemonc.mhmedical.com/content.aspx?aid=1133363078 ER -