TY - CHAP M1 - Book, Section TI - Polyclonal Polycythemias (Primary and Secondary) A1 - Lichtman, Marshall A. A1 - Kaushansky, Kenneth A1 - Prchal, Josef T. A1 - Levi, Marcel M. A1 - Burns, Linda J. A1 - Armitage, James O. Y1 - 2017 N1 - T2 - Williams Manual of Hematology, 9e AB - Polycythemia, also referred to as erythrocytosis, is characterized by an increased red cell mass. There is no consensus on terminology (ie, primary familial polycythemia but postrenal transplantation erythrocytosis). Polycythemias can be primary or secondary and can be inherited or acquired.Classification of polycythemic disorders appears in Table 2–2 in Chap. 2.Primary polycythemias are caused by somatic or germline mutations within hematopoietic stem cells or erythroid progenitors that result in an augmented response to erythropoietin. This response is inappropriate; that is, it is not a compensation for hypoxia.Secondary polycythemias are caused by either an appropriate (compensatory) or inappropriate increase in the red cell mass as a result of augmented levels of erythropoietin. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/03 UR - hemonc.mhmedical.com/content.aspx?aid=1133363268 ER -