TY - CHAP M1 - Book, Section TI - Multiple Endocrine Neoplasia Type 1 A1 - Holt, Shelby A1 - Barron, Alison Unzeitig A1 - Nwariaku, Fiemu A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. Y1 - 2018 N1 - T2 - Textbook of Complex General Surgical Oncology AB - The multiple endocrine neoplasia type 1 (MEN1) syndrome was initially described in 1954 as Wermer’s syndrome. Dr Paul Wermer reported on a syndrome in which adenomatosis of the anterior pituitary, parathyroid, and pancreatic islets was observed in a family in which the father and four of nine siblings were affected.1 He postulated that this syndrome was likely inherited as an autosomal dominant disease and that these patients commonly also suffered from ulcers of the stomach and duodenum. It is now widely known that MEN1 consists of a constellation of multiglandular parathyroid disease, neuroendocrine tumors of the gastroenteropancreatic system, anterior pituitary adenomas, and other associated nonendocrine manifestations such as facial angiofibromas. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - hemonc.mhmedical.com/content.aspx?aid=1145757799 ER -