TY - CHAP M1 - Book, Section TI - Cancer of the Unknown Primary A1 - Wein, Richard O. A1 - O'Leary, Miriam A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. Y1 - 2018 N1 - T2 - Textbook of Complex General Surgical Oncology AB - Carcinoma of unknown primary origin (CUPO) is estimated to represent between 3% and 5% of all head and neck cancer presentations, and can pose a challenge in assessment when diagnosed.1 Metastatic carcinoma from an occult upper aerodigestive tract (UADT) source carries a different prognosis than cancers metastatic to the neck from an infraclavicular source. When patients have a primary site identified, they benefit from the ability to offer site-specific therapy that can reduce the morbidity of treatment. Identification of a primary site also improves the capacity for prognostic counseling while facilitating the long-term assessment for recurrence. With advances in diagnostic imaging, development of new surgical techniques, and the expansion of immunohistochemical (IHC) and gene expression studies for tissue specimens, the assessment of CUPO patients continues to evolve. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1145758703 ER -