TY - CHAP M1 - Book, Section TI - Surgical Strategies for Breast Cancer Risk Reduction A1 - Singh, Puneet A1 - Kulkarni, Swati A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. Y1 - 2018 N1 - T2 - Textbook of Complex General Surgical Oncology AB - Surgical prophylaxis remains the most effective means to prevent breast cancer. Strategies for risk reduction include bilateral prophylactic mastectomy (BPM), contralateral prophylactic mastectomy (CPM), and prophylactic bilateral salpingo-oophorectomy (PBSO). BPM is performed for risk reduction in women who have not been diagnosed with cancer. In contrast, CPM is performed in patients with a diagnosis of unilateral breast cancer for risk reduction of contralateral breast cancer.1 Current guidelines for prophylactic mastectomy (PM) include patients with BRCA1/2 mutations, other predisposing gene mutations, strong family history with no demonstrable mutation, and prior mantle radiation for Hodgkin’s lymphoma, all of which confer a significantly higher risk for breast cancer than for the general population.2,3 Discussion of risk-reduction procedures is complex and should be individualized to ensure the best oncologic and psychosocial outcomes for each patient. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - hemonc.mhmedical.com/content.aspx?aid=1145759946 ER -